光动力疗法治疗典型性及隐匿性脉络膜新生血管后暂时性的浆液性视网膜脱离

• 作 者: Mennel S Meyer C.H Eggarter F Peter S. 陈立军
• 机 构: Department of Ophth almology Philipps-Unive-rsity Marburg Robert-Koch-Str 4 35037 Marburg Germany D
• 出 处: 世界核心医学期刊文摘.眼科学分册
• 发表日期: 2006年02期
• 关键词: 脉络膜新生血管 光动力疗法 隐匿性 视网膜外屏障 视网膜 视网膜下积液 横切面 定量分析 病例研究 后血

PURPOSE: To quantify transient serous retinal detachment in classic and occult choroidal neovascularization (CNV) after photodynamic therapy (PDT). DESIGN: Prospective consecutive case series. METHODS: Consecutive patients with classic and occult CNV were examined by optical coherence tomography before PDT and at 2 and 7 days after PDT. RESULTS: In classic CNV (n=6), retinal elevations increased from 217 (SD 42) μ m before PDT to 626 (SD 157) μ m 2 days after PDT and decreased to 240 (SD 36) μ m 7 days after treatment. In occult CNV (n=4), the mean retinal elevation of 266 (SD 41) μ m before PDT increased to 544 (SD 94) μ m 2 days after PDT and decreased to 259 (SD 40) μ m7 days after treatment. CONCLUSION: Cross-sectional optical coherence tomography imaging revealed transient subretinal fluid accumulation in classic as well as in occult CNV after PDT. The subretinal location possibly relates to an outer blood-retinal barrier breakdown after PDT.

METHODS: Consecutive patients with classic and occult CNV were examined by optical coherence tomography before PDT and at 2 and 7 days after PDT. RESULTS: In classic CNV (n = 6), retinal elevations increased from 217 (SD 42) μ m before PDT to 626 (SD 157) μ m 2 days after PDT and decreased to 240 ) μ m 7 days after treatment. In occult CNV (n = 4), the mean retinal elevation of 266 (SD 41) μ m before PDT increased to 544 (SD 94) μ m 2 days after PDT and decreased to 259 (SD 40) μ m7 days after treatment. CONCLUSION: Cross-sectional optical coherence tomography imaging revealed transient subretinal fluid accumulation in classic as well as in occult CNV after PDT. The subretinal location may be related to an outer blood-retinal barrier breakdown after PDT.