论文部分内容阅读
目的探讨乳腺小管癌的临床病理特征、诊断与鉴别诊断要点。方法通过光镜和免疫组化方法对4例乳腺小管癌进行临床病理分析,结合文献对其临床表现、病理形态特点及鉴别诊断进行探讨。结果4例乳腺小管癌仅3例有可触及的肿物,另1例仅在B超下发现两个低回声肿块。镜下4例均由高分化的小管结构组成,存在开放的管腔,被覆单层上皮细胞,腺管形状不规则成角状,内含嗜碱性分泌物,可见顶浆分泌的小突起,未见肌上皮细胞及完整的基底膜成分,SMA(-)。间质增生并富于细胞。3例伴有导管内癌,其中1例伴有平坦上皮不典型增生。结论小管癌的正确诊断需组织形态和免疫组化相结合,并与硬化性腺病、微小腺体腺病、复杂硬化性腺病/放射状瘢痕、以腺管结构为主的乳腺浸润性导管癌等病变相鉴别。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of breast cancer. Methods Four cases of breast cancer were analyzed by light microscopy and immunohistochemistry. The clinicopathological features, pathological features and differential diagnosis were analyzed based on the literature. Results In 4 cases of breast cancer, only 3 cases had palpable masses, and in the other 1 case, only 2 cases of hypoechoic tumors were found under B-ultrasound. Microscopic 4 cases were composed of highly differentiated tubules, there is an open lumen, monolayer covered epithelial cells, ductular irregular shape into angular, containing basophilic secretions, visible apocrine secretion of small protrusions, No myoepithelial cells and intact basement membrane composition, SMA (-). Interstitial hyperplasia and rich in cells. 3 cases with intraductal carcinoma, including 1 case of flat epithelial dysplasia. Conclusions The correct diagnosis of small ductal carcinoma requires the combination of histomorphology and immunohistochemistry and is associated with sclerosing adenosis, small glandular adenosis, complex sclerosing adenosis / radial scars, breast ductal invasive ductal carcinoma and other lesions Phase identification.