论文部分内容阅读
为探讨脑内儿茶酚胺在高血压形成中的作用,对自发性高血压大鼠(SHR)和正常血压大鼠(WKY)测定了不同脑区NE、E和血管紧张素Ⅱ(AⅡ)的含量。结果表明,SHR在12周龄时,动脉血压明显高于WKY(30.7±1.2 kPa、18.2±0.8kPa)。同时延脑、下丘脑和尾核内的NE与AⅡ含量亦明显比WKY高,NE分别高40.3％、51.2％和75.0％;AⅡ高125.0％、25.2％和46.9％;而E含量明显低于WKY,延脑低25.2％,下丘脑低29.0％。从8周龄SHR侧脑室注射6-OHDA,4 周后上述3个脑区的NE、E和AⅡ含量均显著减少(减少范围在26％～41％),血压上升值亦降低42.9％。提示脑内NE和AⅡ含量异常增加,可能与自发性高血压的形成有关。
To investigate the role of cerebral catecholamines in the development of hypertension, the levels of NE, E and angiotensin Ⅱ (AⅡ) in different brain regions were measured in spontaneously hypertensive rats (SHR) and normal blood pressure rats (WKY). The results showed that at 12 weeks of age, arterial blood pressure of SHR was significantly higher than that of WKY (30.7 ± 1.2 kPa, 18.2 ± 0.8 kPa). At the same time, the contents of NE and AⅡ in the brain, hypothalamus and caudate nucleus were also significantly higher than those in WKY and NE, respectively 40.3%, 51.2% and 75.0% higher than those in WKY; AⅡ were 125.0%, 25.2% and 46.9% WKY, delayed brain 25.2%, hypothalamus 29.0%. From the 8-week-old SHR injected 6-OHDA into the lateral ventricle, the NE, E and AII levels in the three brain regions were significantly reduced (ranged from 26% to 41%) after 4 weeks and the blood pressure increased by 42.9%. Suggesting that the abnormal increase of NE and AⅡ in brain may be related to the formation of spontaneous hypertension.