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采用ELISA法测定了60例丙型肝炎患者血清sIL-2R水平。结果显示,丙型肝炎患者血清sIL-2R水平明显高于正常对照组(P<0.01),急性肝炎高于慢性肝炎(P<0.01)。肝功能损害程度与血清sIL-2R水平呈正相关(r=0.57,P<0.01)。29例HCV-RNA阳性患者应用α-2b干扰素治疗,治疗后血清sIL-2R较治疗前明显下降(P<0.05),其中17例HCV-RNA阴转,阴转组较未阴转组下降明显(P<0.05)。结果提示:血清sIL-2R水平与丙型肝炎患者肝细胞病变程度有关,同时对观察干扰素的疗效亦有所帮助。
Serum sIL-2R levels were measured in 60 patients with hepatitis C by ELISA. The results showed that the level of serum sIL-2R in patients with hepatitis C was significantly higher than that in the control group (P <0.01), acute hepatitis was higher than that in chronic hepatitis (P <0.01). The degree of liver damage was positively correlated with serum sIL-2R level (r = 0.57, P <0.01). 29 cases of HCV-RNA positive patients treated with interferon alfa-2b, serum sIL-2R after treatment decreased significantly (P <0.05), of which 17 cases of HCV-RNA overcast, overcast negative group than the negative overcast group decreased Obviously (P <0.05). The results suggest that the serum level of sIL-2R is associated with the degree of hepatocellular disease in patients with hepatitis C, and it is also helpful to observe the effect of interferon.