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目的对垂体微腺瘤的临床症状体征、内分泌与病理免疫组化类型相关性进行探讨。方法选取2010年1月至2012年12月在本院确诊的垂体微腺瘤患者84例,对其进行内分泌、影像学和病理检查,分析检查结果之间的关系。结果患者出现内分泌症状76例(90.47%),免疫组化阳性组内分泌症状发生率[92.59%(75/81)]较免疫组化阴性组[33.33%(1/3)]高,差异具有显著性(χ2=5.92,P<0.05),表明内分泌症状与免疫组化结果相符。血清泌乳素(PRL)阳性组血清PRL增高及闭经、溢乳或月经失调发生率高于PRL阴性组;生长激素(GH)阳性组血清GH增高及巨人症或肢端肥大发生率高于GH阴性组。结论垂体微腺瘤患者的临床表现、内分泌结果与病理免疫组化类型相关,可用来提高垂体微腺瘤的诊断率与治疗率。
Objective To investigate the correlation between clinical symptoms and signs, endocrine and pathological immunohistochemical types of pituitary microadenomas. Methods Eighty-four patients with pituitary adenoma diagnosed in our hospital from January 2010 to December 2012 were selected for endocrine, radiological and pathological examination, and the relationship between the results was analyzed. Results There were 76 cases of endocrine symptoms (90.47%), the incidence of endocrine symptoms in the immunohistochemical positive group (92.59% (75/81)] was higher than that in the negative group [33.33% (1/3)], the difference was significant (Χ2 = 5.92, P <0.05), indicating that endocrine symptoms consistent with the results of immunohistochemistry. Serum prolactin (PRL) positive serum PRL increased and the incidence of amenorrhea, galactorrhea or menstrual disorders than the PRL negative group; growth hormone (GH) positive serum GH and gigantism or acromegaly incidence was higher than the GH negative group . Conclusion The clinical manifestations and endocrine results of patients with pituitary microadenoma are related to the types of pathological immunohistochemistry and can be used to improve the diagnosis and treatment rate of pituitary microadenomas.