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目的:通过观察发生宫颈病变的妇女的人乳头瘤病毒(HPV)感染情况,比较分析宫颈组织高危型HPV(16/18型)感染与宫颈癌及癌前病变发生的相关性。方法:选取在我院妇科就诊的怀疑有宫颈病变的患者656人,对所有患者进行病理活检及专业的病理诊断,并进行HPV-16和HOV-18的基因学检测,对结果进行分析。结果:与无宫颈病变组比较,CINⅠ组、CINⅡ/Ⅲ组、宫颈癌组高危型HPV DNA阳性率明显增高(P<0.05);与CINⅠ组比较,CINⅡ/Ⅲ组、宫颈癌组的高危型HPV DNA阳性率明显增高(P<0.05);感染HPV-16和HPV-18后,发生宫颈癌的危险度均较高,OR分别为48.85和26.00,发生CINⅡ/Ⅲ的危险度也较高,OR分别为11.59和19.36。结论:宫颈组织高危型HPV(16/18型)感染与宫颈癌及癌前病变发生存在一定的相关关系,建议临床治疗宫颈癌前病变时注意HPV感染,患者应注意自我保护,避免HPV的感染。
OBJECTIVE: To compare the HPV infection of women with cervical lesions and to analyze the correlation between cervical cancer with high-risk HPV (type 16/18) and cervical cancer and precancerous lesions. Methods: A total of 656 suspected cervical lesions were treated in gynecology department of our hospital. Pathological biopsy and pathological diagnosis were performed on all the patients. Genomic examination of HPV-16 and HOV-18 was performed and the results were analyzed. Results: The positive rate of high-risk HPV DNA in CINⅠgroup, CINⅡ / Ⅲgroup and cervical cancer group was significantly higher than that in non-cervical lesions group (P <0.05). Compared with CINⅠgroup, The positive rate of HPV DNA was significantly higher (P <0.05). The risk of cervical cancer was higher after infection with HPV-16 and HPV-18, the ORs were 48.85 and 26.00, respectively. The risk of developing CINⅡ / Ⅲ was also higher, ORs were 11.59 and 19.36, respectively. Conclusion: The high risk HPV type (16/18) infection in cervical tissue is related to the occurrence of cervical cancer and precancerous lesions. It is recommended to pay attention to HPV infection in clinical treatment of cervical precancerous lesions. Patients should pay attention to self-protection and avoid HPV infection .