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目的:探讨９９ｍＴｃ－ＴＲＯＤＡＴ－１ ＳＰＥＣＴ多巴胺转运体(ＤＡＴ)显像对特发性震颤(ＥＴ)、早期帕金森病(ＰＤ)鉴别诊断的价值。方法:对９例ＥＴ,１４例早期ＰＤ,５例ＥＴ合并ＰＤ(ＥＴ－ＰＤ)患者和２０名健康人进行９９ｍＴｃ－ＴＲＯＤＡＴ－１－ＳＰＥＣＴＤＡＴ断层显像。结果:与年龄、性别相配对的正常人相比,ＥＴ患者纹状体(ＳＴ)与小脑(ＣＢ)ＤＡＴ特异性摄取比值(ＳＴ/ＣＢ)无显著性差异,早期ＰＤ和ＥＴ－ＰＤ患者ＳＴ/ＣＢ显著性降低。结论:９９ｍＴｃ－ＴＲＯＤＡＴ－１ＳＰＥＣＴ ＤＡＴ显像有助于ＥＴ、早期ＰＤ的鉴别诊断。
Objective: To investigate the value of 99mTc-TRODAT-1 SPECT dopamine transporter (DAT) imaging in the differential diagnosis of idiopathic tremor (ET) and early Parkinson’s disease (PD). Methods: 99m Tc-TRODAT-1-SPECTDAT imaging was performed in 9 ET, 14 early PD, 5 ET combined with PD (ET-PD) and 20 healthy individuals. Results: There was no significant difference in the ratio of ST / CB to DAT in ET patients compared with age and sex matched normal subjects (ST / CB) / CB significantly reduced. Conclusion: 99mTc-TRODAT-1 SPECT DAT imaging is helpful for the differential diagnosis of ET and early PD.