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目的评价α硫辛酸联合甲钴胺及前列地尔治疗糖尿病周围神经病变(DPN)的疗效。方法将32例患者随机分为两组:治疗组予α-硫辛酸、甲钻胺及前列地尔,对照组予甲钴胺及前列地尔,治疗2周。观察两组临床疗效及神经传导速度(NCV)。结果治疗组总有效率达87.5%,明显高于对照组的50%(P<0.05);两组患者的神经病变主觉症状问卷(TSS)评分明显改善(P<0.05);治疗组NCV较对照组有显著提高(P<0.01)。结论临床使用α-硫辛酸联合甲钻胺及前列地尔治疗DPN安全有效。
Objective To evaluate the efficacy of alpha lipoic acid combined with mecobalamin and alprostadil in the treatment of diabetic peripheral neuropathy (DPN). Methods Thirty-two patients were randomly divided into two groups: the treatment group was given α-lipoic acid, methylamine and alprostadil, and the control group was given mecobalamin and alprostadil for 2 weeks. The clinical efficacy and nerve conduction velocity (NCV) of the two groups were observed. Results The total effective rate of the treatment group was 87.5%, which was significantly higher than that of the control group (P <0.05). The scores of neurological symptoms symptom questionnaire (TSS) were significantly improved in both groups (P <0.05) The control group was significantly increased (P <0.01). Conclusion The clinical use of α-lipoic acid in combination with methylamine and prostaglandin in the treatment of DPN is safe and effective.