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目的探讨不同血尿酸(SUA)水平与非酒精性脂肪肝(NAFLD)的相关性。方法选取2011-2012年度于本院参加健康体检的7 893例作为研究对象,进行统一问卷调查、血液生化及肝脏超声检查。依据基线SUA水平将研究对象四分位分组,比较4组间NAFLD检出率,并对NAFLD的影响因素进行多因素logistic回归分析。结果随着SUA水平的升高,NAFLD的检出率逐渐升高,四组NAFLD检出率分别为29.5%、42.5%、50.5%和63.9%。影响发生NAFLD的多因素logistic回归分析显示:校正了年龄、性别等因素后,与第一分位组比较,第二、三、四分位组发生NAFLD的OR值分别是1.218(95%CI:1.033~1.437)、1.353(95%CI:1.139~1.607)、1.713(95%CI:1.428~2.053)倍(P<0.05)。结论SUA水平升高是发生NAFLD的独立危险因素,与NAFLD的发病密切相关。
Objective To investigate the relationship between different levels of serum uric acid (SUA) and non-alcoholic fatty liver disease (NAFLD). Methods A total of 7 893 cases of physical examination in our hospital from 2011 to 2012 were selected as the research object, and the questionnaires, blood biochemistry and liver ultrasonography were performed. According to the baseline SUA level, the subjects were divided into four groups. The detection rate of NAFLD among the four groups was compared. The factors of NAFLD were analyzed by multivariate logistic regression analysis. Results With the increase of SUA level, the detection rate of NAFLD gradually increased. The detection rates of NAFLD in four groups were 29.5%, 42.5%, 50.5% and 63.9% respectively. The multivariate logistic regression analysis of NAFLD showed that the OR of NAFLD in the second, third and fourth interquartile range was 1.218 (95% CI: 1.033-1.437), 1.353 (95% CI: 1.139-1.607), and 1.713 (95% CI: 1.428-2.05) times (P <0.05). Conclusions The elevated level of SUA is an independent risk factor of NAFLD, which is closely related to the incidence of NAFLD.