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目的 探讨细胞周期蛋白D_1(cyclin D_1)表达与宫颈鳞癌关系的规律,为寻找一种早期诊断的手段奠定基础。方法 采用班点杂交方法检测96例经福尔马林固定,石蜡包埋的宫颈鳞状上皮癌(宫颈鳞癌)38例,宫颈鳞状上皮不典型增生32例、慢性宫颈炎12例和正常宫颈组织标本14例中cyclin D_1的表达情况。结果 cyclin D_1的表达在宫颈鳞癌与不典型增生相差不显著(P>0.05)。显著高于慢性宫颈炎和正常宫颈组织(P<0.05)。结论 揭示cyclin D_1的高表达与宫颈鳞癌的发生有关。
Objective To investigate the relationship between the expression of cyclin D_1 and cervical squamous cell carcinoma and lay the foundation for finding an early diagnosis method. Methods The clinical data of 96 cases of squamous cell carcinoma of the cervix (cervical squamous cell carcinoma) fixed by paraffin embedded in 38 cases, cervical squamous cell atypical hyperplasia in 32 cases, chronic cervicitis in 12 cases and normal The expression of cyclin D_1 in 14 cases of cervical tissue specimens. Results The expression of cyclin D_1 was not significantly different between cervical squamous cell carcinoma and atypical hyperplasia (P> 0.05). Significantly higher than chronic cervicitis and normal cervical tissue (P <0.05). Conclusions The high expression of cyclin D 1 is associated with the occurrence of cervical squamous cell carcinoma.