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急性早幼粒细胞白血病(acutepromyelocytic leukemia,APL)是一种骨髓中有大量异常早幼粒细胞积聚并伴有严重出血倾向的白血病类型,在FAB分型中属M3型急性髓性白血病(AMLM3),以具有t(15;17)染色体易位的细胞遗传学标志为特征。APL是临床上第一个应用诱导分化和针对肿瘤特异性标志分子进行治疗并取得显著疗效的人类
Acute promyelocytic leukemia (APL) is a type of leukemia with a large number of abnormal promyelocytic accumulation in the bone marrow with severe bleeding tendency. It belongs to type Acute myeloid leukemia (AMLM3) in FAB typing, , Is characterized by cytogenetics that have a t (15; 17) chromosomal translocation. APL is the first clinical application of induction of differentiation and tumor-specific marker molecules for treatment and achieve significant efficacy in humans