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Tissue engineering and the tissue engineering model have shown promise in improving methods of drug delivery,drug action,and drug discovery in pharmaceutical research for the attenuation of the central nervous system inflammatory response.Such inflammation contributes to the lack of regenerative ability of neural cells,as well as the temporary and permanent loss of function associated with neurodegenerative diseases such as Alzheimer’s disease,Parkinson’s disease,and traumatic brain injury.This review is focused specifically on the recent advances in the tissue engineering model made by altering scaffold biophysical and biochemical properties for use in the treatment of neurodegenerative diseases.A portion of this article will also be spent on the review of recent progress made in extracellular matrix decellularization as a new and innovative scaffold for disease treatment.