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目的：对分泌性中耳炎患者免疫状态、人白介素2(IL-2)、人γ干扰素(IFN-γ)、耳积液一氧化氮(NO)等指标改变情况进行分析。方法选择2013年5月～2015年9月收治的40例分泌性中耳炎患者作为治疗组研究对象，另选择同期健康体检人员80例作为对照组研究对象，对比两组研究对象免疫状态、LI-2、IFN-γ、耳积液NO等临床指标改善情况。结果相对比对照组研究对象来说，治疗组免疫球蛋白、外周血T淋巴细胞亚群中CD8+等指标较高，其CD4/CD8、CD4+、CD3+等指标较低；LI-2、耳积液NO等指标较高，慢性研究对象具有更大的差异(<0.05)。结论分泌性中耳炎患者免疫状态较差，通过LI-2、IFN-γ、耳积液NO等指标可以对疾病严重程度有着全面的了解，其检测价值较高。“,”Objective On the immune status of patients with secretory otitis media,human interleukin 2(IL 2)and gamma interferon(IFN-gamma),nitric oxide (NO),ear effusion measures such as changing situation are analyzed.Methods In May 2013 to September 2015,40 patients with secretory otitis media were treated as the research object,the treatment group,another to choose the healthy physical examination personnel 80 cases for the same period as the control group the research object,compared to two groups of immune status,LI-2,IFN-gamma,ear effusion NO clinical indexes such as to improve the situation.Results Relatively than the control group for research object,the treatment group of immunoglobulin,peripheral blood T lymphocyte subsets in the indexes of CD8+is higher,the CD4/CD8,CD4+and CD3+index is low;LI-2,ear effusion NO index is higher,such as chronic research object has a bigger difference ( <0.05).Conclusion The immune status of patients with secretory otitis media is poorer,by LI-2,IFN-NO indicators such as gamma,ear effusion can have a comprehensive understanding on the severity of disease,the test value is higher.