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目的探讨N-乙酰半胱氨酸联合顺尔宁对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能和动脉血气指标的改善作用。方法选取AECOPD患者109例,采用随机数字表法将患者分为观察组(n=55)和对照组(n=54),观察组给予N-乙酰半胱氨酸联合顺尔宁药物治疗,对照组给予顺尔宁药物治疗,比较两组患者肺功能和动脉血气指标的差异。结果治疗后,观察组治疗有效率明显增高,一秒用力呼气容积(FEV_1)、用力肺活量(FVC)、FEV_1/FVC、最大呼气中期流速(MMFR)、动脉血氧分压(PaO_2)、氧合指数(PaO_2/FiO_2)水平明显高于对照组,动脉血二氧化碳分压(Pa CO2)、痰液评分明显低于对照组,且全部患者治疗前后上述指标改变差异有统计学意义(P<0.05)。两组患者药物不良反应发生率比较差异无统计学意义(P>0.05)。结论 N-乙酰半胱氨酸联合顺尔宁治疗AECOPD效果满意,有助于改善肺功能和动脉血气指标,提高祛痰效果,值得临床推广应用。
Objective To investigate the effect of N-acetylcysteine combined with cis-ning on the improvement of pulmonary function and arterial blood gas in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods One hundred and nine patients with AECOPD were selected and divided into observation group (n = 55) and control group (n = 54) by random number table. The observation group was given N-acetylcysteine combined with cisplatin, Group treated with Salbutamol medication, pulmonary function and arterial blood gas in two groups were compared. Results After treatment, the effective rate of treatment in observation group was significantly higher than that in control group (FEV_1, FVC, MMFR, PaO_2, The oxygenation index (PaO 2 / FiO 2) was significantly higher than that of the control group. PaCO 2 and phlegm scores of the patients were significantly lower than those of the control group. The changes of these indexes in all patients before and after treatment were significantly different (P < 0.05). There was no significant difference in adverse drug reaction between the two groups (P> 0.05). Conclusion N-acetylcysteine combined with cisplatin is effective in treating AECOPD, which is helpful to improve pulmonary function and arterial blood gas index and improve expectorant effect, which is worthy of clinical application.