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目的探讨米非司酮、米索前列醇片等药物联合宫腔镜治疗早期未破裂型宫角妊娠的疗效。方法对20例早期未破裂型宫角妊娠的患者先口服米非司酮片及阴道后穹窿置米索前列醇片诱发子宫收缩,待排出孕囊后或宫口松弛满意下行宫腔镜手术治疗。结果 20例患者均一次性吸宫清除干净,吸宫时阴道出血10~40 mL,治疗过程中未发生宫角破裂腹腔内出血病例。药流后阴道排出物或清宫后组织病理检查均见绒毛组织。术后β-HCG值1~4周恢复正常。随访14~28个月,患者月经恢复时间35~42d。10例有生育要求者8例已妊娠分娩。结论米非司酮、米索前列醇片等药物联合宫腔镜治疗早期未破裂型宫角妊娠是安全、有效的。
Objective To investigate the efficacy of mifepristone and misoprostol in combination with hysteroscopy in the treatment of early unruptured uterine horn pregnancy. Methods 20 patients with early unruptured uterine horn pregnancy oral mifepristone tablets and vaginal fornix misoprostol tablets induced uterine contractions to be discharged after gestational sac or cervix relaxation satisfactory hysteroscopic surgery . Results All 20 patients were cleaned up one time by suction, and vaginal bleeding was 10 ~ 40 mL at the time of suction. No cases of intrauterine hemorrhage were observed during the treatment. Vaginal discharge after drug or post-Qing histopathological examination showed villous tissue. Β-HCG after 1 to 4 weeks returned to normal. Follow-up 14 to 28 months, the patient’s menstrual recovery time 35 ~ 42d. 10 cases of childbirth requirements in 8 cases of pregnancy delivery. Conclusion mifepristone and misoprostol and other drugs combined with hysteroscopy treatment of early unruptured uterine horn pregnancy is safe and effective.