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目的 初步探讨~(13)N-氨(NH_3)PET动态显像诊断垂体微腺瘤的价值。方法 21例无垂体病史的住院病人行~(13)N-NH_3PET垂体显像,2例垂体微腺瘤患者,均经MRI、内分泌激素测定、临床表现等确诊,进行动态~(13)N-NH_3PET显像。结果 正常垂体~(13)N-NH_3PET显像垂体形态呈类圆形,垂体上缘平坦,垂体高度为1.06±0.12cm,垂体在颈内动脉显影后10s内显影。2例垂体微腺瘤患者垂体形态异常,垂体上缘膨隆,垂体高度分别为1.75cm和1.62cm,垂体显影时间延迟,分别在颈内动脉显影后20s和30s时显影。垂体SUV值分别为3.96和3.28,与丘脑放射性计数比值分别为1.58和1.27。结论 ~(13)N-NH_3PET显像可诊断垂体微腺瘤,其表现为垂体形态异常,垂体上缘膨隆,垂体高度增大,垂体显影时间延迟。~(13)N-NH_3PET显像诊断垂体微腺瘤的机制和价值需进一步研究。
Objective To investigate the value of 13(3)-N-NH3 PET dynamic imaging in the diagnosis of pituitary microadenomas. Methods Twenty-one hospitalized patients with no history of pituitary disease underwent 13-N-NH 3 PET imaging and 2 patients with pituitary microadenomas were diagnosed with MRI, endocrine hormone, and clinical manifestations. The dynamics were performed. 13 N- NH_3PET imaging. Results The pituitary morphology of the normal pituitary ~(13)N-NH_3 PET imaging was round and round, the upper edge of the pituitary was flat, and the height of the pituitary was 1.06±0.12 cm. The pituitary was developed within 10 s after the development of the internal carotid artery. Two patients with pituitary microadenomas had pituitary abnormalities, the upper edge of the pituitary gland bulged, and the pituitary heights were 1.75 cm and 1.62 cm, respectively. The development time of the pituitary was delayed and developed at 20s and 30s after the development of the internal carotid artery. Pituitary SUV values were 3.96 and 3.28, respectively, and the thalamic radioactivity counts were 1.58 and 1.27, respectively. Conclusions ~(13)N-NH3 PET imaging can diagnose pituitary microadenomas with pituitary abnormalities, bulging of the upper edge of the pituitary gland, heightening of the pituitary, and delayed pituitary development. The mechanism and value of ~(13)N-NH3 PET imaging in the diagnosis of pituitary microadenomas need further study.