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一、治疗方法 口服血管紧张素转换抑制剂酶剂巯甲丙脯酸(Captoril,国产),初用剂量为12.5～25mg,每是3次,用药3～7天后,如无不良反应,渐递增至50～75mg,每日3次,共用药20～50天左右(剂量越大,用药时间越短)。如患者临床症状有明显改善,并复查T_3、T_4、SACE正常后开始减量,2个月后服维持量25mg/日,患者服用Captoril期间均未用甲状腺片等影响甲状腺功能的药物。 二、讨论 血管紧张素转换酶(ACE)抑制剂应用于治疗各类心血管疾患日益增多,但临床治疗甲亢,国内外尚未见报道。 ACE抑制剂的药理作用为:阻滞血管紧张素Ⅰ转化为血管紧张素Ⅱ,使血管发生扩张,同时可降低交感神经系统活性,抑制肾素—血管紧张素系统;阻止缓激肽的破坏,使组织激肽浓度增加。因
First, the treatment of oral administration of angiotensin-converting enzyme inhibitor captoril (Captoril, domestic), the initial dose of 12.5 ~ 25mg, each 3 times, after 3 to 7 days medication, if no adverse reactions, the gradual increase To 50 ~ 75mg, 3 times a day, a total of 20 to 50 days or so (the greater the dose, the shorter the time). Such as patients with significant improvement in clinical symptoms, and review T_3, T_4, SACE began to reduce after normal, 2 months after the maintenance dose of 25mg / day, patients taking Captoril were not used thyroid tablets and other drugs that affect thyroid function. Second, the discussion Angiotensin converting enzyme (ACE) inhibitors used in the treatment of various types of cardiovascular disease is increasing, but clinical treatment of hyperthyroidism, has not been reported at home and abroad. The pharmacological actions of ACE inhibitors are as follows: Blocking the conversion of angiotensin I to angiotensin II causes the blood vessels to dilate, reducing sympathetic nervous system activity and inhibiting the renin-angiotensin system; preventing the destruction of bradykinin, Tissue kinin concentration increased. because