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冠心病(coronary atherosclerotic heart diseaseCAD)是人类导致死亡的主要因素之一。2011年世界卫生组织的资料显示我国CAD死亡人数已列居世界第二位。mi RNAs(mi R)是一类在进化上高度保守的单链、非编码小分子RNA[18～22nt],在转录后水平负性调控靶基因的表达。研究表明,mi RNAs参与调节体内许多生理和病理过程,与心血管疾病、糖尿病、肿瘤等多种疾病的发病或预后密切相关~([1])。并且
Coronary heart disease (coronary atherosclerotic heart diseaseCAD) is one of the main causes of human death. According to the information of the World Health Organization in 2011, the death toll of CAD in China ranks second in the world. mi RNAs (mi Rs) are a class of evolutionarily conserved single-stranded, non-coding small RNAs [18-22 nt] that negatively regulate target gene expression at the posttranscriptional level. Studies have shown that miRNAs are involved in the regulation of many physiological and pathological processes in the body and are closely related to the pathogenesis or prognosis of various diseases such as cardiovascular diseases, diabetes and tumors (1). and