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目的探讨饮酒与Barrett食管发生的关系。方法系统检索PubMed、EMBASE、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)等数据库。对纳入研究的文献采用Newcastle-Ottawa量表进行质量评价,根据研究类型、地域、资料来源、饮酒种类分亚组进行分析,综合定量评价饮酒与Barrett食管的关系。结果共纳入16篇文献(病例对照研究13篇,队列研究3篇)累积Barrett食管3 961例,对照11 748例。Meta分析结果显示队列研究亚组中,与不饮酒者相比,饮酒者Barrett食管发病风险OR为1.27(95%CI:1.03～1.58,P=0.03);亚洲地区亚组饮酒者较不饮酒者Barrett食管发病风险高47%(OR=1.47,95%CI:1.10～1.97,P=0.009),美洲地区亚组饮酒使Barrett食管风险降低了17%(OR=0.83,95%CI:0.71～0.96,P=0.02),而其他各亚组合并结果均显示差异无统计学意义(P>0.05)。结论饮酒是患Barrett食管的危险因素;亚洲地区人群饮酒是Barrett食管的重要危险因素。
Objective To explore the relationship between alcohol consumption and Barrett’s esophagus. Methods PubMed, EMBASE, China Biomedical Literature Database (CBM) and Chinese Journal Full-text Database (CNKI) were searched systematically. The Newcastle-Ottawa scale was used to evaluate the quality of the included literature, and the relationship between drinking and Barrett ’s esophagus was quantitatively evaluated based on the type of study, the region, the source of data and the type of drinking. Results A total of 16 articles (13 case-control studies and 3 cohort studies) were enrolled in the study. There were 3 961 cases of Barrett’s esophagus and 11 748 controls. Meta-analysis showed that the risk of Barrett’s esophagus was 1.27 (95% CI: 1.03-1.58, P = 0.03) in the cohort study compared with those who did not drink; Asian sub-group drinkers were less likely to drink alcohol Barrett’s esophageal risk was 47% (OR = 1.47, 95% CI: 1.10-1.97, P = 0.009). Barrett’s esophageal risk was reduced by 17% (R 0.83, 95% CI 0.71-0.96 , P = 0.02), while the results of other subgroups showed no significant difference (P> 0.05). Conclusion Alcohol drinking is a risk factor for Barrett’s esophagus. Drinking alcohol in the Asian region is an important risk factor for Barrett’s esophagus.