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背景:华蟾素是一种从干蟾皮中提取的中药制剂,在多种肿瘤细胞中具有抗肿瘤作用,广泛应用于临床治疗。本研究目的:旨在观察华蟾素联合多西他赛对晚期非小细胞肺癌患者的生活质量及癌痛缓解的疗效。方法:选择50例晚期非小细胞肺癌,随机分为多西他赛单药组或华蟾素联合多西他赛组,每组患者各25例。两组患者均接受治疗2个疗程治疗后,观察其生活质量及癌痛缓解度。结果:华蟾素联合多西他赛组患者生活质量改善,如日常活动、睡眠和心情均显著提高(P<0.05);与单药组比较,华蟾素联合多西他赛组患者癌痛有所减轻(P<0.05)。结论:华蟾素联合多西他赛可有效改善晚期非小细胞肺癌的生活质量及缓解癌性疼痛,可作为晚期非小细胞肺癌辅助化疗的一种中药制剂。
BACKGROUND: Cinobufacini is a traditional Chinese medicine extracted from dried toad skin and has antitumor activity in various tumor cells and is widely used in clinical treatment. The purpose of this study: To observe the cinobufotalin and docetaxel in patients with advanced non-small cell lung cancer quality of life and cancer pain relief. Methods: Fifty patients with advanced non-small cell lung cancer were randomly divided into docetaxel single-agent group and cinobufotalin combined docetaxel group, with 25 patients in each group. Two groups of patients were treated for 2 courses of treatment, observe the quality of life and cancer pain relief. Results: The cinobufotalin combined with docetaxel group improved the quality of life, such as daily activities, sleep and mood were significantly increased (P <0.05); compared with the single drug group, cinobufotalin and docetaxel group of patients with cancer pain (P <0.05). Conclusion: Cinobufacini combined with docetaxel can effectively improve the quality of life and relieve the cancerous pain in patients with advanced non-small cell lung cancer, and can be used as a traditional Chinese medicine for the adjuvant chemotherapy of advanced non-small cell lung cancer.