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1993年12月至1996年4月,我们以紫杉醇为主治疗45例复发转移性乳腺癌患者,取得了较好疗效。现报告如下。1 临床资料 本组患者均符合以下标准:①病理组织学检查证实为乳腺癌;②年龄<70岁;③Karnofsky评分>60分;④有可测量的病灶;⑤骨髓造血功能及肝肾功能正常;⑥有手术史,术后加用化疗或放疗;⑦全身无活动性感染。患者平均年龄45.8岁。其中肺转移19例,胸壁转移24例,骨转移2例;9例为复发。将其随机分为A组(紫杉醇+阿霉素)及B组(环磷酰胺+阿霉素+5-氟脲嘧啶)。其中A组21例(肺转移10例,胸壁转移9例,骨转移2例;复发6例),静滴紫杉醇135mg/m~2,静注阿霉素40mg/m~2。使用紫杉醇时应注意:①用药前日晚9时及当日晨3时各服地塞米松3.75mg,给药前30分钟口服苯海拉明50mg,雷尼替丁100mg加入滴管中静滴;②溶于生理盐水500ml中,3小时
From December 1993 to April 1996, we used paclitaxel as the main treatment for 45 patients with recurrent metastatic breast cancer, and achieved good results. The report is as follows. 1 clinical data in this group of patients are in line with the following criteria: 1 histopathological examination confirmed breast cancer; 2 age <70 years; 3 Karnofsky score> 60 points; 4 measurable lesions; 5 bone marrow hematopoietic function and normal liver and kidney function; 6 There is a history of surgery, plus chemotherapy or radiotherapy after surgery; 7 There is no active infection in the whole body. The average age of the patients was 45.8 years. Among them, 19 cases had lung metastases, 24 cases had chest wall metastases, 2 cases had bone metastasis, and 9 cases had recurrence. They were randomly divided into group A (paclitaxel + adriamycin) and group B (cyclophosphamide + doxorubicin + 5-fluorouracil). Among them, 21 patients in group A (lung metastasis in 10 cases, chest wall metastasis in 9 cases, bone metastasis in 2 cases; recurrence in 6 cases), intravenous paclitaxel 135 mg/m~2, and intravenous adriamycin 40 mg/m~2. Attention should be paid when using paclitaxel: 1 each day before medication and at 3 o’clock in the morning before medication, dexamethasone 3.75mg, oral administration of diphenhydramine 50mg 30min before, drip ranitidine 100mg intravenous drip infusion; 2 dissolved In normal saline 500ml, 3 hours