论文部分内容阅读
目的观察卡维地洛治疗慢性充血性心力衰竭(CHF)的疗效。方法 60例CHF患者随机分为治疗组与对照组,治疗组在常规治疗的基础上,从小剂量开始加用卡维地洛至目标剂量维持;对照组仅采用常规治疗。在治疗12个月后观察2组疗效。结果用药(卡维地洛)12个月后治疗组总有效率为93.3%,明显高于对照组的有效率(66.7%),差异有统计学意义(χ2=6.67,P<0.01)。2组治疗后左室舒张末期内径(LVDd)、左室收缩末期内径(LVSd)、左室射血分数(LVEF)、心率(HR)的变化的差异均有统计学意义(P<0.05),结论在常规治疗基础上从小剂量开始加用卡维地洛治疗CHF,疗效均优于常规治疗,不良反应小,安全性高。
Objective To observe the efficacy of carvedilol in the treatment of chronic congestive heart failure (CHF). Methods Sixty patients with CHF were randomly divided into treatment group and control group. On the basis of routine treatment, the treatment group was given carvedilol at a low dose until the target dose was maintained. The control group was treated with conventional therapy only. After 12 months of treatment, two groups were observed. Results After 12 months of treatment, the total effective rate of the treatment group was 93.3%, significantly higher than that of the control group (66.7%), the difference was statistically significant (χ2 = 6.67, P <0.01). There were significant differences in LVDd, LVSd, LVEF and HR between the two groups after treatment (P <0.05) Conclusion On the basis of routine treatment, the use of carvedilol in the treatment of CHF started from a small dose, and its curative effect was better than that of conventional treatment with small adverse reactions and high safety.