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目的总结药物所致肾功能不全的临床特点,为该病的临床诊断和防治提供参考。方法2006年至2009年收治原发病为药源性慢性间质性肾炎的慢性肾功能不全住院患者的临床资料进行回顾性分析。结果共20例患者,男女比例为1∶4,50岁以下患者5例,50～70岁11例,70岁以上4例。致病药物中去痛片4例,利福平1例,中药15例。处于肾功能不全代偿期3例,失代偿期8例,衰竭期4例,尿毒症期5例。无死亡病例,未愈3例,好转14例,治愈3例。结论慢性肾功能不全是各种慢性肾脏疾病病情发展恶化的结果,作为能够导致慢性肾功能不全的药源性慢性间质性肾炎,一旦确诊应及早治疗。
Objective To summarize the clinical features of drug-induced renal insufficiency and provide reference for the clinical diagnosis and prevention of the disease. Methods From 2006 to 2009, the clinical data of hospitalized patients with chronic renal insufficiency with drug-induced chronic interstitial nephritis were retrospectively analyzed. Results A total of 20 patients, male to female ratio of 1: 4 patients under 50 years of age in 5 cases, 50 to 70 years in 11 cases, 4 cases over the age of 70. Pathogenic drugs to painkillers in 4 cases, 1 case of rifampicin, 15 cases of traditional Chinese medicine. In renal decompensation in 3 cases, decompensated in 8 cases, failure in 4 cases, 5 cases of uremia. No deaths, healed in 3 cases, improved in 14 cases, 3 cases were cured. Conclusions Chronic renal insufficiency is the result of the worsening progression of various chronic kidney diseases. As a chronic drug of chronic interstitial nephritis with chronic renal insufficiency, once diagnosed, it should be treated as soon as possible.