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目的本研究通过检测新疆哈萨克族食管癌组织中MEK1/2、ERK1/2、JAK1/2、STAT3和c-myc的表达,探讨调控c-myc表达的主要信号传导通路。方法对52例新疆哈萨克族食管癌组织及远端正常组织,采用RT-PCR检测c-myc的表达,并在c-myc差异表达的标本中检测MEK1/2、ERK1/2、JAK1/2及STAT3的表达水平。结果 c-myc在肿瘤组织中显著高表达(P<0.05)。其中,ERK2和STAT3均与c-myc的表达呈正相关(P<0.05),而JAK1/2和ERK1则与c-myc的表达无关;但ERK2与MEK1、MEK2和STAT3的表达呈正相关(P<0.05);此外,ERK1与MEK1和MEK2的表达也呈正相关(P<0.05)。结论在新疆哈萨克族食管癌发生发展过程中,可能通过MEK/ERK2/STAT3信号传导通路调控c-myc,而JAK/STAT3信号途径可能不是激活c-myc的主要途径。
OBJECTIVE: To investigate the expression of MEK1 / 2, ERK1 / 2, JAK1 / 2, STAT3 and c-myc in esophageal squamous cell carcinoma of Kazakh in Xinjiang, and to explore the main signaling pathways regulating the expression of c-myc. Methods The expression of c-myc was detected by RT-PCR in 52 Kazakh esophageal cancer tissues and distal normal tissues. The expressions of MEK1 / 2, ERK1 / 2, JAK1 / 2 and c-myc STAT3 expression levels. Results c-myc was significantly higher in tumor tissue (P <0.05). Among them, ERK2 and STAT3 were positively correlated with the expression of c-myc (P <0.05), while JAK1 / 2 and ERK1 had no correlation with the expression of c-myc, but ERK2 was positively correlated with the expression of MEK1, MEK2 and STAT3 (P < 0.05). In addition, there was a positive correlation between the expression of ERK1 and MEK1 and MEK2 (P <0.05). Conclusions During the development of esophageal cancer in Kazak in Xinjiang, c-myc may be regulated by MEK / ERK2 / STAT3 signal transduction pathway, while JAK / STAT3 signaling pathway may not be the main pathway for activation of c-myc.