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饮酒是一种口腔癌和咽喉癌的强风险因子。酒精脱氢酶3型(ADH_3)代谢乙醇形成乙醛,后者是一种致癌剂。作者评估快代谢ADH_3~1等位基因(ADH_3~(1-))的纯合个体是否比慢代谢ADH_3~2等位基因(ADH_3~(1-2)和ADH_3~(2-2))的个体,在饮酒时有发生口腔癌更大的风险。 方法 用口腔上皮细胞样本的分子遗传学分析确定,137例有组织学确诊口腔癌和146例对照组(即没有口腔癌病史的个体)的ADH_3~(1-1)基因型,用多因子logistic回归分析估测风险。 结果 与有ADH_3~(1-1)基因型不饮酒者比较,至少每
Drinking alcohol is a strong risk factor for oral and throat cancer. Alcohol dehydrogenase type 3 (ADH_3) metabolizes ethanol to form acetaldehyde, the latter being a carcinogen. The authors assessed whether homozygous individuals with ADH_3 ~ 1 alleles (ADH_3 ~ (1-)) in the fast metabolizing group were significantly more likely to be metabolized than those with the slower ADH_3 ~ 2 alleles (ADH_3 ~ (1-2) and ADH_3 ~ (2-2) Individuals, oral alcohol occur at greater risk of oral cancer. Methods Using molecular genetic analysis of oral epithelial samples, 137 ADH_3 ~ (1-1) genotypes with histologically confirmed oral cancer and 146 control subjects (ie, individuals without a history of oral cancer) were analyzed by multivariate logistic Regression analysis estimates the risk. Results Compared with ADH3 ~ (1-1) genotype non-drinkers, at least every one