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本文应用放免测定法,观察了再障、骨髓增生异常综合征(MDS)和消化道肿瘤合并贫血患者血清和红细胞铁蛋白含量变化。结果表明:血清铁蛋白(SF)和红细胞铁蛋白(RBC·F)虽然均为铁贮指标,但在不同类型贫血中显示出不同的变化规律。早期、轻型再障病人铁代谢异常首先反映出RBC·F改变,晚期、重症病人则可伴有SF升高。MDS患者,除铁代谢异常波及SF和RBC·F改变外,体内的恶性克隆细胞合成铁蛋白增加也可导致SF、RBC·F升高。消化系统肿瘤并贫血患者存在多种可使SF升高的因素,但RBC·F改变仅只受铁代谢影响,可以较可靠地提供体内贮铁情况。
In this paper, the changes of serum and erythrocyte ferritin levels in patients with aplastic anemia, myelodysplastic syndrome (MDS) and gastrointestinal cancer with anemia were observed by radioimmunoassay. The results showed that serum ferritin (SF) and erythrocyte ferritin (RBC · F) were indicators of iron storage, but showed different changes in different types of anemia. Early, light aplasia patients with iron metabolism abnormalities first reflect the change of RBC · F, advanced, severe cases may be associated with increased SF. MDS patients, in addition to iron metabolism abnormalities affect the SF and RBC · F changes, the body of malignant cloned cells increased synthesis of ferritin can also lead to SF, RBC · F increased. In patients with digestive system anemia and anemia, there are many factors that can increase SF. However, the change of RBC · F is only affected by iron metabolism and can provide the iron storage in the body more reliably.