ANALYSIS OF CLINICAL CHARACTERISTICS AND DEATH RELATED FACTORS OF SEVERE MECONIUM ASPIRATION SYNDR

• 作 者: 朱建幸 周晓玲 孙波 张宇鸣 沈月华 孙眉月
• 机 构: Department of Pediatrics, Xinhua Hospital, SSMU, Shanghai 200092, China,Department of Pediatrics, X
• 出 处: Journal of Shanghai Second Medical University
• 发表日期: 2003年02期
• 关键词: 陈克正 tress hypoxic median grave stained Death 国维 param plications

Objective To investigate the factors in relation with the case fatality in severe meconium aspiration syndrome (MAS). Methods Eighty-one severe MAS cases intervened by the mechanical ventilation from 9 childrens hospitals were retrospectively analyzed for the risk factors of fatality with SAS software for non-parametric rank sum test and chi-square test. Results In the 81 cases, 49 were survived (death rate 39%). The gestational age (GA), Apgars score at 1min and other complications with MAS were significantly related to the death (P <0.05). There was no difference of death rate between the patients with or without receiving endotracheal intubation and airway suctioning (P>0.05). Conclusion A higher death rate (close to 40%) of severe MAS in the middle of 1990s in major cities of China suggests that it is important to detect the intrauterine hypoxemia as it may indicated by meconium staining amniotic fluid which should be intervened early by adequate termination of pregnancy before 42 weeks. The effects of delivery room suction and conventional ventilation also need to be reevaluated.

Objective To investigate the factors in relation with the case fatality in severe meconium aspiration syndrome (MAS). Methods Eighty-one severe MAS cases intervened by the mechanical ventilation from 9 children’s hospitals were retrospectively analyzed for the risk factors of fatality with SAS software for gestational age (GA), Apgar’s score at 1min and other complications with MAS were significantly related There was no difference of death rate between the patients with or without receiving endotracheal intubation and airway suctioning (P> 0.05). Conclusion A higher death rate (close to 40%) of severe MAS in the middle of 1990’s in major cities of China suggests that it is important to detect the intrauterine hypoxemia as it may be indicated by meconium staining amniotic fluid which should be intervened early by adequate termination of preg nancy before 42 weeks. The effects of delivery room suction and conventional ventilation also need to be reevaluated.