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目的探讨2型糖尿病患者的尿微量白蛋白、糖化血红蛋白、空腹血糖、血脂与糖尿病肾病病变程度的相关性及早期诊断和治疗的价值。方法对109例2型糖尿病患者和80例健康者进行尿微量白蛋白、糖化血红蛋白、空腹血糖、血脂水平的检测,将两组结果进行比较分析。并将糖尿病组根据糖化血红蛋白的测定值分为低值组(HbA1c<7.0%)、中值组(HbA1c7.1%～10.0%)、高值组(HbA1c>10.0%)。结果糖尿病组的HbA1c、FBG、mALB、TG、TC、LDL-C的浓度显著高于正常对照组(P<0.01),HDL-C的浓度显著低于正常对照组(P<0.05)。随着HbA1c水平的增高,mALB、FBG水平随之增高,二者之间呈显著正相关(P<0.01)。结论糖尿病患者的尿微量白蛋白增高程度与糖化血红蛋白的增高有关,尿微量白蛋白是糖尿病早期肾损伤的灵敏指标,联合检测HbA1c和mALB对糖尿病肾病的早期预防、诊断和治疗有重要意义。
Objective To investigate the correlation between urine microalbumin, glycosylated hemoglobin, fasting blood glucose, blood lipids and diabetic nephropathy in type 2 diabetic patients and the value of early diagnosis and treatment. Methods The urine microalbumin, glycosylated hemoglobin, fasting blood glucose and blood lipids in 109 type 2 diabetic patients and 80 healthy people were measured. The results of two groups were compared and analyzed. The patients in the diabetes group were divided into low-value group (HbA1c <7.0%), median group (HbA1c7.1% -10.0%) and high-value group (HbA1c> 10.0%) according to the measured value of glycosylated hemoglobin. Results The concentrations of HbA1c, FBG, mALB, TG, TC and LDL-C in diabetic group were significantly higher than those in normal control group (P <0.01). The concentrations of HDL-C in diabetic group were significantly lower than those in normal control group (P <0.05). With the increase of HbA1c level, the level of mALB and FBG increased significantly (P <0.01). Conclusions The increase of urinary albumin in diabetic patients is related to the increase of HbA1c. Urinary microalbumin is a sensitive indicator of early renal injury in diabetic patients. Combined detection of HbA1c and mALB is of great significance in the early prevention, diagnosis and treatment of diabetic nephropathy.