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拔毛癖是一种以强迫性拔毛发为特征的疾病,DSM-Ⅲ-R将其归类于冲动控制障碍中。它与强迫症(OCD)、抽动秽语综合征(TS)关系密切。假设将拔毛癖与TS也归在与强迫有关的疾病中,那么这类疾病应有一致的现象学及有关神经生理学基础。Swedo等研究认为,五羟色胺(5-HT)回收抑制药氯丙咪嗪治疗拔毛癖较去甲肾上腺素回收抑制药去甲咪嗪效果好,与治疗OCD的结果一致。而神经阻滞药作为TS的首选药,与氯丙咪嗪合用治疗难治性OCD有效。那么拔毛癖是否如此?作者首次提出氯丙咪嗪与哌迷清合用治疗拔毛癖。方法:所有病例均符合DSM-Ⅲ-R拔毛
Trichotillomania is a disorder characterized by obsessive plucking of hair, which DSM-III-R classifies as an impulse control disorder. It is closely related to OCD and TS. Assuming that tachyotic disorder and TS are also classified as obsessive-compulsive disorders, then there should be consistent phenomenology and neurophysiological basis for such disorders. Swedo and other studies suggest that serotonin (5-HT) revertant drug clomipramine treatment of trichotillomania than norepinephrine recuperation inhibitor delipramine good effect, consistent with the results of the treatment of OCD. The nerve block drugs as the drug of choice for TS, and clomipramine combined treatment of refractory OCD effective. So if trichotillomania is the case? The authors first proposed clomipramine and piperidazole combined treatment of trichotillomania. Methods: All cases were consistent with DSM-Ⅲ-R plucking