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七只家兔暴露于低压舱,每天4小时,连续两周。第一周与第二周的模拟海拨高度分别为3800和5000m。阶梯低氧适应后,适应组家兔与对照组家兔(n=8)一同暴露于模拟海拔5000m,停留3小时。其中适应组家兔的V_D/V_T、Qs/Qt、DL阻力和P_(50)分别为0.31、5.6%、8.7mmHg和23.4mmHg;而对照组家兔的上述指标依次为0.43、17.1%、10.9mmHg和26.0mmHg(p<0.05)。本实验结果表明,间断低氧适应之所以能提高PaO_2和减小AaDO_2,可能与V_D/V_T.Qs/Qt.DL阻力减小和P_(50)左移有关。
Seven rabbits were exposed to a hypobaric chamber for 4 hours a day for two weeks. The simulated altitude for the first and second weeks was 3800 and 5000 m respectively. After the step hypoxia adaptation, rabbits in the adaptation group and the control group (n = 8) were exposed to a simulated altitude of 5000 m for 3 hours. The V_D / V_T, Qs / Qt, DL resistance and P_ (50) were 0.31,5.6%, 8.7mmHg and 23.4mmHg in rabbits in control group, while those in control rabbits were 0.43,17.1% and 10.9 mmHg and 26.0 mmHg (p <0.05). The experimental results show that the reason why intermittent hypoxia adaptation can increase PaO_2 and decrease AaDO_2 may be related to the decrease of V_D / V_T.Qs / Qt.DL resistance and P_ (50) left shift.