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自1975年在先天性心脏病婴儿使用前列腺素E_1(PGE_1)和 E_2(PGE_2)保持动脉导管开放以来,发现不同婴儿其动脉导管对 PGE 的反应性有所差别。本文对15只妊娠晚期的羊羔进行了实验室研究,旨在探索调节动脉导管对 PGE 反应能力的因素。
Since 1975, the use of prostaglandin E_1 (PGE_1) and E_2 (PGE_2) to keep the patent ductus arteriosus open in infants with congenital heart disease has found differences in the reactivity of PAs in different infants with ductus arteriosus. In this paper, 15 pregnant women in the third trimester of pregnancy conducted a laboratory study to explore the regulation of ductus arteriosus PGE response factors.