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目的:探讨急性白血病免疫表型特点及其与预后的关系。方法 :用间接免疫荧光法对 10 8例急性白血病行免疫表型检测。 结果 :1初诊按 FAB标准诊断的 M2 、M5和 L3各 1例 ,最后确诊为急性混合细胞性白血病( MAL) ;4例急性未分化型白血病 ( UAL)确诊为急性髓细胞白血病微分化型 ( M0 )。 2 AL L 中 11.5 %伴有髓系抗原表达 ;B- AL L中 CD34 +明显高于 T- AL L (分别为 5 3%和 2 8% ) ,但差异无统计学意义 ( P >0 .0 5 ) ,骨髓内原始 +幼稚细胞数 T- AL L明显低于 B- AL L ( P <0 .0 5 )。 3AML中 2 2例 ( 2 7.8% )伴有至少一个淋系抗原表达。 4CD7+- AML 中 CD34 、CD38、HL A- DR等早期干 /祖细胞抗原高表达 ,CD7在 M3中低表达而在 M0 M1 中高表达 ( P<0 .0 1)。 结论:免疫表型分析对 MAL和 M0 的诊断不可缺少 ;CD7+- AML提示预后差
Objective: To investigate the immunophenotypic characteristics of acute leukemia and its relationship with prognosis. Methods: The immunophenotypes of 108 acute leukemia patients were detected by indirect immunofluorescence. Results: 1 The first diagnosis of M2, M5 and L3 diagnosed by FAB standard was first diagnosed as acute mixed leukemia (MAL); 4 cases of acute undifferentiated leukemia (UAL) were diagnosed as acute myeloid leukemia differential type M0). The expression of myeloid antigen was found in 11.5% of ALT patients. CD34 + of AL-L was significantly higher than that of T-AL L patients (53.3% and 28.0% respectively), but the difference was not statistically significant (P> 0.05). 0 5). The number of naive + naive cells in bone marrow was significantly lower than that of B-AL L (P <0.05). Twenty-two cases (2 7.8%) of 3 AML had at least one lymphoid antigen expression. CD34, CD38, HL-DR and other early stem / progenitor antigens were highly expressed in 4CD7 + - AML. CD7 was low in M3 but highly expressed in M0 M1 (P <0.01). CONCLUSION: Immunophenotyping is indispensable for the diagnosis of MAL and M0; CD7 + - AML suggests poor prognosis