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目的:探讨雌激素受体β(ERβ)在喉癌中表达情况以及其与上皮细胞间质转化生物标志物(EMT)间的关系。方法:采用Picture MT-Pv9000免疫组织化学技术检测72例喉癌及8例癌旁组织中ERβ及EMT的表达情况。结果:ERβ在癌组织和癌旁组织表达阳性率分别为27.78%、25.00%,差异无统计学意义(P>0.05),E-钙黏着蛋白(E-cadherin)和β-连环素(β-catenin)的异常表达率分别为61.11%、76.39%。ERβ阳性表达与E-cadherin表达的缺失及β-catenin的核转位、TNM分期增高成负相关(P<0.05)。结论:ERβ表达与喉癌分化、临床分期、颈淋巴结转移密切相关,其阳性表达提示喉癌预后良好,其机制可能与E-cadherin、β-catenin的异常表达有关。
Objective: To investigate the expression of estrogen receptor β (ERβ) in laryngeal carcinoma and its relationship with epithelial cell mesenchymal transition biomarkers (EMT). Methods: The expression of ERβ and EMT in 72 cases of laryngeal carcinoma and 8 cases of paracancerous tissues were detected by Picture MT-Pv9000 immunohistochemistry. Results: The positive expression rate of ERβin cancer tissues and paracancer tissues was 27.78% and 25.00%, respectively, with no significant difference (P> 0.05). E-cadherin and β-catenin (β- The abnormal expression rates of catenin were 61.11% and 76.39% respectively. The positive expression of ERβ was negatively correlated with the deletion of E-cadherin expression and nuclear translocation of β-catenin and TNM staging (P <0.05). Conclusion: The expression of ERβ is closely related to the differentiation, clinical stage and cervical lymph node metastasis of laryngeal carcinoma. The positive expression of ERβ suggests the good prognosis of laryngeal carcinoma, which may be related to the abnormal expression of E-cadherin and β-catenin.