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许多临床报告指出,大剂量抗坏血酸(V_c)有益于各种应激状况,如烧伤、损伤、外科手术和感染。Pauling根据临床试验的结果和V_c的无毒性质,推荐一个成年人,每日的热量需要为2,500千卡时,V_c的每日供给量为2g或更多。但另一些学者则对大剂量V_c在预防及有益作用的问题上持怀疑态度。大剂量V_c对正常生物功能的影响则缺乏肯定的资料。认为免疫机制是受V_c影响功能之一,白细胞的吞噬作用和杀菌活力为宿主抵御感染的主要机制。人类多形核白细胞吞噬过程伴随了氧化代谢的较大改变,包括-磷酸己糖旁路(HMS)活性的增加。已证明,白细胞的HMS
Many clinical reports indicate that high doses of ascorbate (V_c) are beneficial for a variety of stress conditions such as burns, injuries, surgeries and infections. Based on the results of clinical trials and the non-toxic nature of Vc, Pauling recommends an adult with a daily caloric requirement of 2,500 kcal and a daily feed of Vc of 2 g or more. Others, however, are skeptical of the high dose of V_c on the prevention and beneficial effects. Large doses of V_c on the normal biological function of the lack of positive information. It is considered that the immune mechanism is one of the functions affected by V_c. The phagocytosis of leucocytes and the bactericidal activity are the main mechanisms for the host to resist infection. Human polymorphonuclear leukocyte phagocytosis accompanies major changes in oxidative metabolism, including an increase in hexose phosphate hexose (HMS) activity. It has been demonstrated that HMS of leukocytes