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采用18-冠-6(18C6)为相转移催化剂,制备了一系列不同单体比例的聚[1,3-双(对羧基苯氧基)丙烷-癸二酸]共聚酸酐P(CPP-SA),并优化了聚合反应条件。P(CPP-SA)化学结构由傅里叶红外光谱(FT-IR)和核磁共振氢谱(1 H-NMR)表征,并通过特征黏度计算了P(CPP-SA)的黏均分子量。结果表明最佳的反应条件是18C6的用量20%,反应时间15h,P(CPP-SA)特征黏度可达到1.2dL/g,黏均分子量为2.02×105。将P(CPP-SA)置于pH=7.4的磷酸缓冲溶液中进行体外降解,结果表明,降解率与CPP/SA比例有关,其中P(CPP-SA)(CPP/SA=50/50mol/mol)的共聚酸酐降解率与降解时间接近线性关系,具有较好的应用前景。
A series of poly [1,3-bis (p-carboxyphenoxy) propane-sebacic acid] anhydride P (CPP-SA ), And optimize the polymerization conditions. The chemical structure of P (CPP-SA) was characterized by FT-IR and 1 H-NMR, and the viscosity average molecular weight of P (CPP-SA) was calculated by intrinsic viscosity. The results showed that the optimal reaction conditions were as follows: the amount of 18C6 was 20%, the reaction time was 15h, the intrinsic viscosity of P (CPP-SA) was 1.2dL / g and the viscosity average molecular weight was 2.02 × 105. The degradation of P (CPP-SA) in pH = 7.4 phosphate buffer solution in vitro showed that the degradation rate was related to the ratio of CPP / SA with CPP / SA = 50/50 mol / mol ) Of the copolymer anhydride degradation rate and degradation time close to a linear relationship, has a good prospect.