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目的 :回顾分析经动脉超选择热栓塞化疗治疗肝癌后碘油沉积和疗效的关系。方法 :随机将 6 9例肝癌患者分为两组 ,实验组灌注热碘油栓塞剂 (5 5℃～ 6 5℃ )和化疗药与生理盐水混合剂 ,经微导管注入肝癌滋养动脉。对照组热碘油栓塞剂和化疗药与生理盐水温度控制在 2 0℃。术后复查甲胎蛋白 (AFP)及 CT,独立盲法评价碘油沉积情况及肿瘤大小变化 ,对比两组肝癌患者生存率。结果 :实验组碘油沉积 :良好 36例、不良 3例 ,与对照组对比有极显著差异 (P<0 .0 0 1)。实验组生存率 :6个月、12个月、18个月、2 4个月、36个月、4 8个月分别为 :10 0 %、97%、90 %、79%、6 2 %、38% ,与对照组对比有显著差异 (P<0 .0 5 )。结论 :热化疗栓塞治疗肝癌 ,其操作简单 ,碘油沉积良好 ,能显著提高疗效 ,延长患者生存期
Objective: To retrospectively analyze the relationship between lipiodol deposition and efficacy after transcatheter arterial superselective thermochemoembolization in the treatment of liver cancer. Methods: Sixty-nine patients with hepatocellular carcinoma (HCC) were randomly divided into two groups. The experimental group was infused with heat-oil embolization agent (55 ℃ ~ 65 ℃) and chemotherapeutic drugs and saline mixture and injected into the nourishing artery through the microcatheter. The control group of thermal lipiodol embolic agents and chemotherapy drugs and saline temperature control at 20 ℃. AFP and CT were examined after operation, and the deposition of lipiodol and the size of tumor were evaluated by independent blind method. The survival rates of two groups of patients with HCC were compared. Results: Lipiodol deposition in the experimental group was excellent in 36 cases and poor in 3 cases, which was significantly different from the control group (P <0. 001). The survival rate of the experimental group was 60%, 12 months, 18 months, 24 months, 36 months and 48 months respectively: 10%, 97%, 90%, 79%, 62% 38%, compared with the control group were significantly different (P <0. 05). Conclusion: Thermochemotherapy and embolization for the treatment of liver cancer, its simple operation, lipiodol deposition is good, can significantly improve the efficacy and prolong survival of patients