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[Objective] To optimize the inclusion process of 6-gingerol in RHIZOMA ZINGIBERIS,so as to improve the stability of RHIZOMA ZINGIBERIS.[Method] The inclusion complex was prepared by grinding method,and the inclusion process was optimized by orthogonal design.In addition,content of 6-gingerol was determined by HPLC,and the processes was assessed by weight grade method,i.e.inclusion rate(0.6),yield of inclusion complex(0.2) and 6-gingerol percentage(0.2) as indicators.[Result] The optimum inclusion processes were as follows:RHIZOMA ZINGIBERIS density of 1.08(25 ℃),solid-liquid ratio of 1:2(RHIZOMA ZINGIBERIS/water,W/V),grinding duration of 1.0 h,alcohol extract-β-cyclodextrin ratio of 1.5:10.0(W/W).[Conclusion] The optimized inclusion process obtained in this study is reasonable,feasible,reproducible and efficient,which can be used for supervising the production of β-cyclodextrin-6-gingerol inclusion complex.
[Objective] To optimize the inclusion process of 6-gingerol in RHIZOMA ZINGIBERIS, so as to improve the stability of RHIZOMA ZINGIBERIS. [Method] The inclusion complex was prepared by grinding method, and the inclusion process was optimized by orthogonal design. , content of 6-gingerol was determined by HPLC, and the processes were assessed by weight grade method, ieinclusion rate (0.6), yield of inclusion complex (0.2) and 6-gingerol percentage The optimum inclusion processes were as follows: RHIZOMA ZINGIBERIS density of 1.08 (25 ° C), solid-liquid ratio of 1: 2 (RHIZOMA ZINGIBERIS / water, W / V), grinding duration of 1.0 h, alcohol extract-β-cyclodextrin ratio of 1.5: 10.0 (W / W). [Conclusion] The optimized inclusion process obtained in this study is reasonable, feasible, reproducible and efficient, which can be used for supervising the production of β-cyclodextrin-6-gingerol inclusion complex.