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通过增加血管通透性为主的急性炎症模型和以肉芽肿为特征的慢性炎症模型 ,观察赤土苻苓 (Smi)的抗炎作用 ,并以阿斯匹林作为阳性对照。结果 :Smi对二甲苯所致小鼠耳廓肿胀、醋酸引起的小鼠腹腔毛细血管通透性、小鼠角叉菜胶性足肿胀均有明显的抑制作用 ,其中Smi在 80mg/kg作用最为明显 (P <0 .0 0 1)。对小鼠棉球肉芽肿增生也有明显的抗增生作用 (P <0 .0 0 1)。结果表明Smi对急性和慢性炎症模型均有抗炎作用 ,此外 ,Smi明显降低小鼠角叉菜胶性炎症组织内PGE2 含量 (P <0 .0 0 1)。
The anti-inflammatory effect of Smi was observed by increasing the acute inflammation model mainly based on vascular permeability and the chronic inflammation model characterized by granuloma, and aspirin was used as a positive control. RESULTS: Smi significantly inhibited swelling of the ear of mice induced by xylene, acetic acid-induced capillary permeability of mice’s abdominal cavity, and mouse carrageenan foot swelling. Smi was most effective at 80 mg/kg. Significantly (P < 0.01). There was also a significant antiproliferative effect on granulomatous proliferation in mice with cotton balls (P < 0.01). The results showed that Smi had anti-inflammatory effects in both acute and chronic inflammation models. In addition, Smi significantly decreased PGE2 content in mouse carrageenan inflammatory tissues (P < 0.01).