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凋亡抑制蛋白(inhibitor of apoptosis protein,IAP)是一类在结构上具有同源性的细胞内源性凋亡抑制蛋白家族,目前为止在人类已经发现的IAPs至少有8种,它们能够对抗各种凋亡诱导因素,抵抗细胞凋亡。X-连锁调亡抑制蛋白(X-linked inhibitorof apoptosis protein,XIAP)是IAP家族的重要成员,定位于Xq24-25,编码区由7个外显子组成,cDNA全长2540 bp,mRNA全长为9kb,但实际编码区仅有1.5 kb,XIAP含497个氨基酸,分子量为57 kD,主要由3个杆状病毒IAP重复序列区(baculoviral in-hibitorof apoptosis repeat,BIR)和一个RING锌指结构域(RINGZn finger domain)组成。XIAP与细胞凋亡和信号转导[1]密切相关,已成为近年来生命科学研究热点[2,3],本文就XIAP功能调节机制综述如下。
Inhibitor of apoptosis protein (IAP) is a family of structurally homologous endogenous apoptosis-inhibitory proteins. So far, there are at least 8 IAPs that have been found in humans, Apoptosis inducing factors, resist cell apoptosis. The X-linked inhibitor of apoptosis protein (XIAP), an important member of IAP family, is located in Xq24-25. The coding region consists of 7 exons and has a full-length cDNA of 2540 bp. 9kb, but the actual coding region is only 1.5 kb. XIAP contains 497 amino acids and has a molecular weight of 57 kD. It consists of three baculoviral in-hibitor of apoptosis repeats (BIRs) and one RING zinc finger domain (RINGZn finger domain) composition. XIAP is closely related to apoptosis and signal transduction [1], which has become a hot research topic in life science in recent years [2,3]. XIAP functional regulation mechanism is summarized as follows.