对“吸收度比值法”求算溶出度的商榷

• 作 者: 瞿文
• 机 构: 上海医药工业研究院 上海200437
• 出 处: 中国医院药学杂志
• 发表日期: 2001年12期
• 关键词: 溶出度 比值法 吸收度 累积溶出百分率 振摇 精密称定 黄芩甙 药物浓度 人工胃液 药物溶出

溶出度已成为许多难溶性药物、缓释制剂的常规检测项目。求算溶出度时往往需先测定溶出杯中各时间点的药物浓度 ,再求算累积溶出百分率。但近来发现多种供医药专业本科及专科学生使用的教科书中 ,采用吸收度比值法来计算溶出度。经反复考虑 ,认为欠妥。如 1997版《中药药剂学》

Dissolution has become a routine test item for many poorly soluble drugs and sustained release preparations. Dissolution is often required to determine the dissolution of the cup at each time point before the drug concentration, and then calculate the cumulative percentage of dissolution. But recently found a variety of textbooks for medical undergraduate and junior college students, the use of absorbance ratio method to calculate the dissolution. After repeated consideration, that defective. Such as the 1997 version of “Chinese Pharmacy”