精氨酸可减轻顺铂肾毒性

• 作 者: 刘勇
• 出 处: 中国肿瘤
• 发表日期: 2001年05期
• 关键词: 肾毒性 精氨酸 广谱抗癌 实体瘤 舒张血管 细胞膜结构 临床研究结果 上皮细胞变性 肾血管 肾小管细胞

顺铂是常用广谱抗癌药物 ,广泛用于各种实体瘤的化疗 ,但大剂量使用可产生肾毒性。目前国内外多采用水化和应用利尿剂等方法进行预防 ,但尿中β２ ＭＧ仍然升高。山东省临沂市肿瘤医院内一科副主任医师王京芬等日前完成了“Ｌ 精氨酸预防大剂量顺铂化疗所致急性肾毒性的临床研?

Cisplatin is a commonly used broad-spectrum anti-cancer drug and is widely used for chemotherapy of various solid tumors, but renal toxicity can be caused by large doses. At present, hydration and application of diuretics have been used for prevention at home and abroad, but urinary β2 MG is still elevated. Wang Jingfen, deputy chief physician of Linyi City Cancer Hospital of Shandong Province, has completed a clinical trial of “L-arginine to prevent acute nephrotoxicity caused by large doses of cisplatin chemotherapy.”