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虽已明确定义了突触前和突触后α肾上腺素能受体,但更好的分类方法是不管其位置而把它们分为α_1和α_2受体。大鼠血管床具有突触后α_2受体,α肾上腺素能药物如可乐宁和B-HT系列化合物通过它而产生缩血管效应,而选择性的α_2拮抗剂则可阻断该效应。在中枢神经系统内,这一问题较不明确。虽知α受体也分两个亚型,但其在突触内的定位尚未确定。U’Prichard等用[~3H]可乐宁作的结合实验表明,6-羟基多巴胺不能减
Although presynaptic and post-synaptic [alpha] adrenergic receptors have been clearly defined, a better classification is to classify them as alpha 1 and alpha 2 receptors regardless of their location. The rat vascular bed possesses postsynaptic alpha 2 receptors through which α-adrenergic drugs such as clonidine and B-HT family compounds vasoconstrictor effects, whereas selective alpha 2 antagonists block this effect. In the central nervous system, this issue is less clear. Although the alpha receptor is also divided into two subtypes, its location within the synapse has not yet been determined. U’Prichard et al [~ 3H] Clonidine for binding experiments showed that 6-hydroxy dopamine can not be reduced