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本文研究了一种制备缓释丸的新方法,既可用于制备高分子生物活性物质的缓释丸剂,也适用于制备低分子量药物的缓释丸剂。本法主要是在低温和放射线作用下利用能形成聚合物的单体聚合成稳定玻璃态聚合物,并将药物包合其中而成。制备过程,首先将聚合物单体,药物与一种聚合物混合成混悬液,再逐滴加到低温(-78°)的沉淀介质中,于-78°(干冰-甲醇)或-24°以1×10~6拉德/小时
This paper studies a new method for preparing sustained-release pills, both for the preparation of sustained-release high polymer bioactive pills, but also for the preparation of low-molecular weight drug sustained-release pills. This law is mainly in the low temperature and radiation under the action of the polymer can form a monomer polymerization into a stable glassy polymer, and the drug package which is made. The preparation process involves first mixing the polymer monomer, drug, and a polymer into a suspension which is then added dropwise to a low temperature (-78 °) precipitation medium at -78 ° (dry ice-methanol) or -24 ° at 1 × 10 -6 rad / hr