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目的:探讨雌激素受体(ER)α、β亚型的表达量在子宫平滑肌瘤发病中的意义。方法:取自愿手术的子宫肌瘤患者30例为研究对象,应用非放射性原位杂交技术方法测定平滑肌瘤组织中ERα和ERβmRNA的表达,并与正常的平滑肌组织相比较。结果:ERαmRNA和ERβmRNA主要在平滑肌细胞中表达。子宫肌瘤和正常的平滑肌组织中ERαmRNA的表达量高于ERβmRNA;ERαmRNA在子宫肌瘤中的表达明显高于正常的平滑肌组织,而ERβmRNA的表达仅呈下降趋势。结论:子宫肌瘤的发生发展可能与ERαmRNA的高表达有关,亦可能与ERβmRNA减少趋势有关。
Objective: To investigate the significance of the expression of estrogen receptor α and β subtypes in the pathogenesis of uterine leiomyomas. Methods: Totally 30 patients with uterine leiomyoma who underwent voluntary surgery were enrolled in this study. The expression of ERα and ERβ mRNA in leiomyoma was measured by non-radioactive in situ hybridization and compared with normal smooth muscle. Results: ERα mRNA and ERβ mRNA were mainly expressed in smooth muscle cells. The expression of ERαmRNA in uterine fibroids and normal smooth muscle tissues was higher than that in ERβmRNA. The expression of ERαmRNA in uterine fibroids was significantly higher than that in normal smooth muscle tissues, while the expression of ERβmRNA showed only a decreasing trend. Conclusion: The occurrence and development of uterine fibroids may be related to the overexpression of ERαmRNA, and may also be related to the decreasing trend of ERβmRNA.