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目的 探讨小剂量培哚普利对野战条件下血尿(FCH)的治疗及预防作用。方法 329例患者,男309例,女20例。年龄18～21岁,平均(21.2±11)岁。随机分为两组。培哚普利组165例,培哚普利2mg,1次/d;同时休息;预防者培哚普利2mg,1次/d,演习间歇停服。未用培哚普利组164例,均采用心理和休息进行治疗及预防。两组FCH预防期间均由一线卫生人员进行血压(BP)监测,2次/d。以两组FCH消失、BP正常或演习结束为统计界限。结果 两组临床疗效比较差异有显著性意义(P<0.05);两组FCH消失后又再次参加演习者培哚普利组FCH再发率显著低于未用培哚普利组(P<0.01),两组均未出现2次以上再发。培哚普利组血压较演习前(≤120/80mmHg)升高(≥120/80mmHg)率明显低于未用培哚普利组(P<0.01);培哚普利组在治疗及预防期间均未发生不良反应。结论 小剂量培哚普利治疗及预防FCH安全、可靠。
Objective To investigate the therapeutic and preventive effects of low dose perindopril on hematuria (FCH) under field conditions. Methods 329 patients, 309 males and 20 females. Age 18 to 21 years, mean (21.2 ± 11) years. Randomly divided into two groups. Perindopril group 165 cases, perindopril 2mg, 1 times / d; rest at the same time; preventive perindopril 2mg, 1 times / d, intermittent exercise. 164 cases without perindopril group were treated with psychotherapy and rest and prevention. Blood pressure (BP) monitoring was conducted by first-line health workers during the FCH prevention period in both groups, 2 times / d. FCH disappeared in both groups, BP normal or exercise ended as a statistical boundary. Results There was significant difference between the two groups in the clinical curative effect (P <0.05). The recurrence rate of FCH in the perindopril group was significantly lower than that in the non-perindopril group (P <0.01) ), Two groups did not appear more than 2 times recurrence. The perindopril group had significantly lower blood pressure (≥120 / 80mmHg) than preinduction group (≤120 / 80mmHg) than that without perindopril group (P <0.01) No adverse reactions occurred. Conclusion The low dose of perindopril can prevent and treat FCH safely and reliably.