论文部分内容阅读
黄芩甙是从中药黄芩中提取而得,具有清热解毒、抗菌消炎之功,临床上亦有制成栓剂应用。栓剂中基质占栓剂组成比例较大,不仅赋予药物成型,对药物发挥疗效亦有一定的影响。为了进一步探讨基质对黄芩甙释放的影响,本实验研究采用了转兰法,并选用了聚氧乙烯硬脂酸酯(S—40)、甘油明胶、可可豆脂、半合成山苍子酯四种不同的基质,用热熔法制备成肛门栓。每粒栓剂中含黄芩甙0.4g。然后进行释放度测定。为了便于比较,在制备栓剂时不加其他附加剂。测定释放度时选用了蒸馏水和人工肠液两种不同的介质。实验结果表明:四种不同基质的黄芩甙栓在人工肠液中(PH=7.2)释放度均大于在蒸馏水中(PH=6)的释放度。从而可知在制备黄芩甙
Astragalus is extracted from the traditional Chinese medicine Astragalus membranaceus. It has the functions of clearing heat, detoxifying, antibacterial and anti-inflammatory. It has also been used as a suppository in clinical practice. Suppository matrix accounted for a large proportion of suppository composition, not only gives the drug molding, but also has a certain impact on the efficacy of drugs. In order to further investigate the effect of matrix on the release of jaundice, this study used the transfer method, and used polyoxyethylene stearate (S-40), glycerol gelatin, cocoa butter, semi-synthetic cubeba ester Different kinds of bases are made into anal plugs by hot melt method. Each suppository contains 0.4 g of Astragalus. Then release was measured. For ease of comparison, no other additives are added when preparing suppositories. Two different media, distilled water and artificial intestinal juice, were used to determine the release rate. The experimental results show that the release degree of Huangqi suppository in artificial intestinal fluid (PH=7.2) of four different substrates is greater than that in distilled water (PH=6). It can be seen that the preparation of jaundice