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目的探讨老年骨质疏松与动脉硬化的关系。方法测定100例老年患者(60～93岁)血脂、碱性磷酸酶(ALP)、血钙、血磷、高敏C反应蛋白(hs-CRP)。用双能X线骨密度仪测定腰椎(L_(2-4))、股骨颈、大转子及Ward’s三角骨矿密度(BMD)。用高分辨率彩超测定颈动脉内中膜厚度(IMT)。结果骨质疏松组年龄、hs-CRP和IMT均较非骨质疏松组高(均P<0.05),两组性别、体质指数(BMI)、血脂、ALP、血钙和血磷差异无统计学意义(均P>0.05);主动脉硬化组年龄、hs-CRP和IMT均较非主动脉硬化组高(均P<0.05),而L_(2-4)、股骨颈及大转子BMD均较非主动脉硬化组低(均P<0.05),两组性别、BMI、血脂、ALP、血钙和血磷差异无统计学意义(均P>0.05);相关分析表明L_(2-4)、股骨颈、大转子及Ward’s三角BMD与颈动脉IMT呈负相关(均P<0.05)。结论骨质疏松与动脉硬化密切相关,炎症反应可能是骨质疏松与动脉硬化发病机制的共同基础。
Objective To investigate the relationship between senile osteoporosis and arteriosclerosis. Methods Serum lipids, alkaline phosphatase (ALP), serum calcium, phosphorus and high-sensitivity C-reactive protein (hs-CRP) were measured in 100 elderly patients (60-93 years old). Lumbar spine (L_ (2-4)), femoral neck, greater trochanter and Ward’s triangular bone mineral density (BMD) were measured by dual energy X-ray absorptiometry. Carotid artery intima-media thickness (IMT) was measured by high-resolution color Doppler ultrasound. Results The age, hs-CRP and IMT in the osteoporosis group were significantly higher than those in the non-osteoporosis group (all P <0.05). There was no significant difference in the sex, body mass index (BMI), serum lipids, ALP, (All P> 0.05). The age, hs-CRP and IMT of aortic atherosclerosis were higher than those of non-atherosclerosis group (all P <0.05), while the BMD of L 2-4, femoral neck and greater trochanter were There was no significant difference in gender, BMI, serum lipid, ALP, serum calcium and serum phosphorus between the two groups (all P> 0.05). Correlation analysis showed that L 2-4, The femoral neck, greater trochanter and Ward’s triangle BMD were negatively correlated with carotid IMT (all P <0.05). Conclusion Osteoporosis is closely related to arteriosclerosis. Inflammatory reaction may be the common basis of the pathogenesis of osteoporosis and atherosclerosis.