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本文报告 88例病人住院期间药物不良反应(ADR)的调查结果。ADR发生率39％(34/88),男36％(14/39),女41％(20/49),p>0.05。≤49岁病人ADR发生率21/41,显著高于≥50岁病人13/47,p<0.05。因ADR入院的病人2％(2/88)。使用药物721次,发生ADR54次,其中≤49岁组8.8％(37/420),≥50岁组5.6％(17/301),p<0.005。在154种药物中35种发生ADR,抗生素占首位32％(17/54)。ADR累及胃肠道次数最多,其次为神经和皮肤。调查表明,住院天数超过40d,ADR发生率比少于40d的显著为高。
This article reports the results of a survey of 88 adverse drug reactions (ADRs) in hospitalized patients. The incidence of ADR was 39% (34/88), 36% (14/39) male and 41% female (20/49), p> 0.05. The incidence of ADR in patients ≤49 years old was 21/41, significantly higher than 13/47 in patients ≥50 years old, p <0.05. 2% of patients admitted to hospital for ADR (2/88). There were 721 ADRs taking place, of which 54 were ADRs, with 8.8% (37/420) in ≤49 years of age and 5.6% (17/301) in ≥50 years of age, p <0.005. Of 154 medications, 35 developed ADR, with antibiotics being the first 32% (17/54). ADR involved the most gastrointestinal tract, followed by nerve and skin. Surveys show that the hospital stay more than 40d, ADR incidence was significantly higher than less than 40d.