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用SD大鼠100只,雌雄各半,其中雌雄各20只自由饮用05%醋酸铅重蒸水溶液,其余饮用不含铅重蒸水.染毒90d,抽查血铅.染毒大鼠血铅均数为281μmol/L,显著高于非染毒大鼠的466μmol/L.停止染毒后,将上述动物按实验设计要求分为5组,按1∶1合笼交配.交配2周后取出雄鼠,使母鼠自然分娩.子代大鼠于出生后8周每窝抽取4～5只,雌雄各半,用Y型迷路进行神经行为功能测定.测定结果表明,父代、母代染毒,或父母均染毒的子代大鼠的学习、记忆能力均显著低于对照组,母鼠在哺乳期染毒的子代大鼠的学习、记记能力与对照组比较略有差异,但差异不显著.以上研究结果提示,铅的神经毒作用可通过父、母的遗传作用而影响到子代,使子代的神经行为功能及智力发育受损
100 SD rats were randomly divided into male and female rats, of which 20 were free to drink redistilled water of 05% lead acetate and the remaining drinking water was free of lead and distilled water. Was 281μmol / L, significantly higher than non-exposed rats 466μmol / L. After stopping the exposure, the above animals were divided into five groups according to the experimental design requirements, mating by 1: 1 cage. 2 weeks after mating males were removed , So that mothers natural childbirth offspring rats at 8 weeks after birth, each puff 4 to 5, male and female, with Y-shaped labyrinthine neurobehavioral determination.Results show that the parents, the mother of the poisoning, Or both offspring and offspring were significantly lower in learning and memory ability than those in the control group. There was a slight difference in learning and memory abilities between the offspring and the control group Not significant.The above results suggest that the neurotoxic effect of lead can affect the offspring through the genetic effects of the father and mother so that the offspring’s neurobehavioral function and mental development are impaired