高分辨光学相干断层成像术对棉絮状白斑进行活体组织学观察

• 作 者: Kozak I. Bartsch D.-U. Freeman W.R. 曹绪胜
• 机 构: Jacobs Retina Center University of California San Diego,Shiley Eye Center,San Diego,CA,United States
• 出 处: 世界核心医学期刊文摘.眼科学分册
• 发表日期: 2006年09期
• 关键词: 棉絮状 活体组织 成像术 白斑 视网膜组织 断层 眼底检查 眼底照相 视网膜病变 光学

PURPOSE:To provide optical characteristics of cotton-wool spots(CWS)on optical coherence tomography(OCT)and scan the retina after CWS have ophthalmoscopically disappeared.DESIGN:Observational case reports.METHODS:We studied four eyes of four patients with retinopathy due to human immunodeficiency virus(HIV)and hypertension.The StratusOCT Model 3000 in single-line mode was used for imaging of acute and resolved CWS and adjacent normal retina.The fundus photography served as a template for OCT scanning in localization of CWS.Retinal tissue reflectivity images were compared.RESULTS:There were differences in reflectivity of normal retina,the retina in the area of active CWS,and the retina in the same area after CWS has resolved.Most striking was that the OCT documented a persistent focal area of hyperreflectivity in the area of the resolved CWS,indicative of retinal gliosis that could be imaged.CONCLUSIONS:CWS show a hyper-reflective pattern on OCT that persists even after they become ophthalmoscopically invisible.

PURPOSE: To provide optical characteristics of cotton-wool spots (CWS) on optical coherence tomography (OCT) and scan the retina after CWS have ophthalmoscopically disappeared. DESIGN: Observational case reports. METHODS: We studied four eyes of four patients with retinopathy due to human immunodeficiency virus (HIV) and hypertension. The Stratus OCT Model 3000 in single-line mode was used for imaging of acute and resolved CWS and adjacent normal retina. The fundus photography served as a template for OCT scanning in localization of CWS. Retinal tissue reflectivity images were compared .RESULTS: There were differences in reflectivity of normal retina, the retina in the area of ​​active of CWS, and the retina in the same area after CWS has resolved. Stud striking was that OCT documented a persistent focal area of ​​hyperreflectivity in the area of ​​the resolved CWS, indicative of retinal gliosis that could be imaged. CONCLUSIONS: CWS show a hyper-reflective pattern on OCT that persists even after they become opht halmoscopically invisible.